AICAR, also known as ZMP, is a peptide. It’s an analogue of AMP, which can stimulate the AMPK or AMP-dependent kinase activity. It was also an intermediate within the inosine monophosphate generation and connected to metabolic regulation. AICAR is best as an inclusion to an endurance stack. Athletes also use it for performance-enhancing in sports where they need endurance.
HISTORY OF AICAR
The medical use of AICAR is to restrict ischemia or the tissues’ blood supply. In the 1980s, they sometimes use for preserving the heart’s blood flow. AICAR also has a promise when it comes to treating diabetes because of its capability of increasing the tissues’ metabolic ability, which it does by modifying the muscle’s composition.
HOW AICAR WORKS
When AICAR triggered the AMPK, it will lead to the cells of the skeletal muscle to take up glucose. In the studies conducted by the Salk Institute and Howard Hughes Medical Centre, the mice given with AICAR were able to run by 44% without needing to train. It’s not surprising that when athletes heard about this compound, they began to use it without fearing testing or regulation up until 2011.
POTENT ENDURANCE STACKING WITH AICAR AND GW-501516
The dosages for AICAR can range from 150 mg every day, if you stack it with GW, to around 500 mg per day when you use it on its own. Every bottle usually comes in 50 mg dosages, so it’s evidently expensive as already stated before. For this reason, it makes sense to use it in the last four weeks before the day of the competition.